The Effect of Chemotherapy on Olfactory and Gustatory Function in Pediatric Patients
Abstract
Background:
Side effects from chemotherapy have been thoroughly studied in the literature, with reports of nausea, fatigue, among many other symptoms. Additionally, very few studies have analyzed the effects of chemotherapeutic agents on olfactory and gustatory function. To date, no study has looked at the effects of chemotherapy on gustatory and olfactory function in the pediatric population. The purpose of our study is multifaceted in its approach: (1) To investigate the effect on gustatory and olfactory function of pediatric patients. (2) To understand the association between gustatory/olfactory dysfunction on the overall nutritional status of pediatric patients.
Methods:
Pediatric patients undergoing chemotherapy will be subjected to three tests analyzing olfactory and gustatory function. The Sniffin' Stick identification test and the Snap and Sniff Threshold test will be used to gather olfactory function. Furthermore, Burghart Odofin Taste Strips will be utilized to test the gustatory function of the participants. To analyze nutritional status, patients will be given questionnaires in the beginning and at the end of the study. An ANOVA test will be used to compare the effects of the various chemotherapeutic agents on olfactory and gustatory function.
Results:
Upon IRB approval, we hope to begin testing on the pediatric patient population at CHKD. We anticipate that there will be a statistically significant difference in the results based on the chemotherapeutic agent used. Furthermore, we anticipate the same trend in gustatory function due to the close relationship of olfaction and gustation.
Conclusion:
As pediatric cancer continues to significantly impact patients across the globe, further research is warranted to better council the patient population regarding the adverse events of treatment. This study will provide more information regarding the adverse events of chemotherapeutic agents given to children. Furthermore, it will help researchers better understand the olfactory and gustatory system and how it is impacted by pharmacology.