The governance board will develop the vision and strategic priorities, applicable policies, and oversee the institute's activity. Members of the governance board include:
- Richard V. Homan, MD, President, Provost and Dean of the School of Medicine, EVMS
- William J Wasilenko, PhD., EVMS Vice Dean for Research
- Alfred Z. Abuhamad, MD, Vice Dean for Clinical Affairs, EVMS
- Carolyn Carpenter, Sentara Norfolk General Hospital President
- Michael Reagin, Chief Information Officer, Sentara Healthcare
- Tom Lundquist, MD, Chief Medical Officer, Optima Health